| Publisher | Los Alamos National Laboratory | ||
|---|---|---|---|
| Format | 87.3KB PDF | Date added | 30 Jun 2006 |
| Topics | Web Services | ||
| Downloads | 4 | ||
Bio-ontologies such as the Gene Ontology (GO) are increasingly important as researchers seek to standardize vocabulary and integrate results into a common framework. They are also being used as the basis for critical bioinformatics tasks, including function prediction and protein family classification. These ontologies are often large (the GO currently contains on the order of 20,000 concepts), making them unamenable for semantic web architectures that need rapid access to only a few terms across many ontologies. Additionally, the common practice of building ontologies with deep, fixed subsumption assertions (e.g., successive, nested owl:subClassOf assertions) means that creating these ontologies is a low-throughput, labor intensive task, yielding third-party extensions vulnerable to fragility and rigidity.
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