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A Parallel Algorithm for Finding Small Sets of Genes That Are Enough to Distinguish Two Biological States

PublisherUniversidade de Sao Paulo
Format631.2KB PDFDate added21 Sep 2004
Topics Parallel Processing, Software Engineering
Downloads7

GCLASS is an algorithm which explores small samples of two distinct biological states for finding small sets of genes, which form a feature vector that is enough to separate these two states. A typical sample is a set of 60 microarrays, 30 for each biological state, with several thousand genes. The technique consists of the following: a spreading model defined in the space of small sets of genes studied and centered in each feature vector considered; the designing of optimal linear classifiers under this spreading model; and ranking the designed classifiers, based on their error and robustness relative to the spreading. The feature vectors used in the best classifiers are considered the best feature vectors.

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