| Publisher | Siemens | ||
|---|---|---|---|
| Format | 640.3KB PDF | Date added | 01 Sep 2005 |
| Topics | Streaming Media, Multimedia | ||
| Downloads | 16 | ||
Extensive evidence now exists that screening for Down syndrome can be provided to women in the first trimester of pregnancy that exceeds the effectiveness of current second trimester serum screening. Screening by a combination of Nuchal Translucency (NT) and two blood markers, free beta hCG and PAPP-A, have a Down syndrome detection rate approaching 90% for a 5% screen-positive rate. Two large NICHD-sponsored USA studies (BUN1 and FASTER2) have produced results that support the effectiveness of first trimester screening. The American College of Obstetricians and Gynecologists released a Committee Opinion3 in July 2004 endorsing first trimester screening using a combination of NT, free beta hCG, and PAPP-A.
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