One of the major impediments to the successful engineering of replacement tissues for grafting and organ repair is the adequate vascularization of the new tissue. New blood vessels are necessary to support the health and homeostasis of tissue grafts. Moreover, the capillary network supporting engineered tissues could be used to deliver growth factors or drugs to the tissue itself. The identification of molecular switches regulating the formation and growth of blood vessel capillaries (vasculogenesis and angiogenesis) is a necessary step for designing new practical strategies for optimizing graft neovascularization and/or for maintaining the endogenous vascular network in grafted or engineered tissue. Key regulatory molecules controlling the growth and differentiation of capillaries could be targeted using peptidomimetics or exogenous genes to optimize the controlled growth of a supportive blood vessel network in new tissues. However, there is first a need for studying in detail the cells giving rise to capillaries and the genes controlling the signaling pathways making the different endothelia compatible with their destined tissue environments.
Did you find this white paper useful?
18 out of 37 users found this white paper useful
Related white papers
Vorteile der High Performance Computing Cluster (HPCC)
Angesichts zunehmend komplexer Rechenanforderungen und wachsender Datens?e verlangen die Kunden h?e Rechenkapazit?n zu geringeren Preisen. High Performance Computing Clustering (HPCC) stellt eine L?g dar, die eine leistungsf?ge Implementierung von Rechenleistung...
HPCC(High Performance Computing Cluster)ÀÇ ÀÌÁ¡
aa ??? ¾?¡ º¹"?v°?µ¥ ? º?® ±???v¸? °?µ? ?¾ ´:·?? °¡°?¸·?¸???¼?? ¿¬»?³¸® ´?€» ¿??°?´? HPCC´ ¸??·‡?¿¬»??´?€» f°? ¼??; f°??µ °??º´·?? ???¿?·?µ??? ?¼???¸¦ »??´ °?¡ º? ³?«³ª :·?? ? ´? ¼¼? ³»¿? ¿???¹?¦...
High Performance Computing Cluster (HPCC) Benefits
As computational needs continue to grow in complexity and larger data sets require analysis, customers are requiring higher levels of computational capability at much lower price points. High Performance Computing...
Dell PowerEdge 3250 Info Brief
The PowerEdge 3250 server utilizes the Intel Itanium Processor Family and scalable cluster technologies to deliver cost effective, scalable solutions designed for compute intensive applications. Learn how this technology...
Biotechnology and Medical Innovation: Socio-Economic Assessment of the Technology, the Potential and the Products
This report considers how the tools of economic assessment may be applied to innovations in health care deriving from modern biotechnology. It combines papers on the science and technology; on assessment...
Pacific Northwest National Laboratory (PNNL) – Itanium® 2 and Linux-based systems
This case study details how the world's fastest Linux-based supercomputer, running on Intel(r) Itanium(r) 2 processors, helped the Pacific Northwest National Laboratory quickly compute complex, long-running simulations.
Sloan Digital Sky Survey and Johns Hopkins University Frame the Universe with the Help of Itanium®-based systems from Hewlett-Packard.
The Sloan Digital Sky Survey, the most ambitious astronomical survey project ever undertaken, is the latest in an ancient and honorable tradition of surveying the sky. The continued progress...
